| PPARG基因单核苷酸多态性与2型糖尿病血脂异常的相关性研究 |
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| 引用本文： | 唐新,林婴,黄文芳,饶绍琴,张本,马誓,刘晓琦,杨正林,尹一兵.PPARG基因单核苷酸多态性与2型糖尿病血脂异常的相关性研究[J].检验医学,2009,24(3):190-193. |
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| 作者姓名： | 唐新 林婴 黄文芳 饶绍琴 张本 马誓 刘晓琦 杨正林 尹一兵 |
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| 作者单位： | 1. 重庆医科大学医学检验系,重庆市,400016
2. 四川省人民医院人类疾病基因研究四川省重点实验室,四川,成都,610072 |
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| 摘 要： | 目的研究PPARG基因单核苷酸多态性（SNPs）与中国汉族2型糖尿病（DM）及血脂异常的关系。方法测定593例2型DM患者及626名正常健康者SNPsrs1801282、rs12636454和rs11128597基因型，分析其与2型DM及血脂水平的关系。基因分型采用单碱基延伸法（SBE）。结果2型DM组SNPs rs1801282、rs12636454和rs11128597基因型及等位基因频率分布与对照组间差异均无统计学意义（P〉0．05）。2型DM组中rs1801282AB＋BB基因型总胆固醇（TC）、血糖和低密度脂蛋白胆固醇（LDL—C）水平显著高于AA基因型（P均〈0．01）。rs1l2636454AA基因型三酰甘油（TG）水平高于AB＋BB基因型（P〈0．05）。rs11128597AA基因型血糖水平高于AB＋BB基因型（P〈0．01）。结论PPARG基因与中国汉族人2型DM无直接相关，但可能参与2型DM的血糖水平和脂质代谢的调节。
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| 关 键 词： | PPARG基因 单核苷酸多态性 血脂 2型糖尿病 |
The investigation of relationship between PPARG gene single nucleotide polymorphisms and blood lipid abnormality in patients with type 2 diabetic mellitus |
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| TANG Xin,LIN Ying,HUANG Wenfang,RAO ShaoQin,ZHANG Ben,MA Shi,LIU Xiaoqi,YANG Zhenglin,YIN Yibing.The investigation of relationship between PPARG gene single nucleotide polymorphisms and blood lipid abnormality in patients with type 2 diabetic mellitus[J].Laboratory Medicine,2009,24(3):190-193. |
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| Authors: | TANG Xin LIN Ying HUANG Wenfang RAO ShaoQin ZHANG Ben MA Shi LIU Xiaoqi YANG Zhenglin YIN Yibing |
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| Institution: | TANG Xin, LIN Yin , HUANG Wenfan , RAO ShaoQin , ZHANG Ben , MA Shi , LIU Xiaoqi , YANG Zhenglin, YIN Yibing ( 1. Department of Laboratory Medicine, Chongqing University of Medical Sciences, Chongqing 400016, China ;2. Sichuan Provincial Key Laboratory for Hunum Disease Gene , Sichuan Academy of Medical Science ＆ Sichuan Provincial Peoples＇ Hospital ,Sichuan Chengdu 610072, China) |
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| Abstract: | Objective To investigate the relationship between the single nucleotide polymorphisms（SNPs） of eroxi- some proliferator-activated receptor-gamma （PPARG）gene and blood lipid abnormality in patients with type 2 diabetic mcllitus（DM） in Chinese Han population. Methods The SNPs of PPARG gene （rs1801282, rs12636454 and rsl 1128597 ）in 593 patients with type 2 DM and 626 healthy controls were determined, and relationship between PPARC gene SNPs and lipid abnormality and patients with type 2 DM SNPs genotyping were performed by a method of Single Base Extension （SBE）. Results There were not significant differences in genotypes and allele frequency distribution of rs1801282, rs12636454 and rsl 1128597 between patients with type 2 DM and healthy controls（ P 〉 0.05 ）. In type 2 DM patients, the serum levels of total cholesterol （TC） , fasting serum glucose（Glu） and low density lipoprotein-cholester- o1（LDL-C） in AB ＋ BB genotypes of rs1801282 were significantly higher than those in AA genotype（P 〈0.01 ） ,the serum level of triglyceride（TG） in AA genotype of rs12636454 was significantly higher than that in AA ＋ AB genotypes （ P 〈 0.05 ）, the serum level of Glu in AA genotype of rsl 1128597 was significantly higher than that in AA ＋ AB genotypes （ P 〈 O. 01 ）. Conclusions The PPARG gene polymorphisms probably has no correlation with the type 2 DM in the Chinese Han population. However,they may participate in the regulation of blood glucose level and lipid metabolism of type 2 DM. |
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| Keywords: | PPARG gene Single nucleotide polymorphism Blood lipid Type 2 diabetes mellitus |
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