胰腺癌与糖尿病相关性调查

[目的]探讨胰腺癌与糖尿病的相关性,为胰腺癌的早期诊断提供依据.[方法]对2004年1月—2008年4月间收治的92例胰腺癌患者和随机抽查的同期住院患各种消化道疾病患者92例(对照组)进行分析,调查胰腺癌与糖尿病间的关系,并在胰腺癌组内进行年龄、肿瘤发生部位及糖尿病病程的比较,探讨胰腺癌合并糖尿病患者的临床特征.[结果]胰腺癌组患者中合并糖尿病者均无糖尿病家族史.合并糖尿病者为19例(21%),显著高于对照组,其中糖尿病的发病先于胰腺癌者为15例,其中糖尿病病程短于2年者为7例,长于5年者为6例,与胰腺癌同时发现者为4例;合并与未合并糖尿病的胰腺癌患者年龄和肿瘤发生部位间均无显著性差异.[结论]胰腺癌患者的糖尿病患病率明显高于对照组,且糖尿病病程的延长可使患胰腺癌风险的增加,认为糖尿病可能是胰腺癌的发病危险因素,两者具有相关性.

Study of correlation between pancreatic cancer and diabetes mellitus

OBJECTIVE To study the correlation between pancreatic cancer and diabetes mellitus(MD) to provide clues for early diagnosis of pancreatic cancer.METHODS It was analyzed the correlation between pancreatic cancer and MD in 92 cases of pancreatic cancer and matched up 92 cases of non-pancreatic cancer be in hospital from Jan,2004 to Apr,2008,and the age,location of tumorigenesis and course of DM were compared within the pancreatic cancer group,and the clinical characteristics of patients with pancreatic cancer complicated by DM.RESULTS Pationts with DM in pancreatic cancer group had no family history of DM.The pancreatic cancer with DM was 19 cases(21%) that was significantly higher than those in control group,in which development of DM before pancreatic cancer was 15 cases, course of DM less than 2 years was 7 cases and more than 5 years is 6 cases,and development of DM with pancreatic cancer discovered at the same time was 4 cases.The age and tumor location had no significant difference between patients of pancreatic cancer with and without DM.CONCLUSION The prevalence of DM was significantly higher in patients with pancreatic cancer than in control group,and course extention of DM increases the risk of suffering from pancreatic cancer,and DM may be one of risk factors for development of pancreatic cancer.