Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome |
| |
Authors: | Giovanni Barbara Cesare Cremon Roberto De Giorgio Giovanni Dothel Lisa Zecchi Lara Bellacosa Giovanni Carini Vincenzo Stanghellini Roberto Corinaldesi |
| |
Institution: | Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy. giovanni.barbara@unibo.it |
| |
Abstract: | Visceral hypersensitivity is currently considered a key pathophysiological mechanism involved in pain perception in large
subgroups of patients with functional gastrointestinal disorders, including irritable bowel syndrome (IBS). In IBS, visceral
hypersensitivity has been described in 20%–90% of patients. The contribution of the central nervous system and psychological
factors to visceral hypersensitivity in patients with IBS may be significant, although still debated. Peripheral factors have
gained increasing attention following the recognition that infectious enteritis may trigger the development of persistent
IBS symptoms, and the identification of mucosal immune, neural, endocrine, microbiological, and intestinal permeability abnormalities.
Growing evidence suggests that these factors play an important role in pain transmission from the periphery to the brain via
sensory nerve pathways in large subsets of patients with IBS. In this review, we will report on recent data on mechanisms
involved in visceral hypersensitivity in IBS, with particular attention paid to peripheral mechanisms. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|