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| 盐酸普鲁卡因经皮离子导入的研究 | |
| 引用本文： | 许东航,缪国娟,梁文权.盐酸普鲁卡因经皮离子导入的研究[J].中国现代应用药学,1999,16(5):18-20. |
| 作者姓名： | 许东航 缪国娟 梁文权 |
| 作者单位： | 1. 杭州,310009,浙江医科大学附属第二医院药剂科 2. 萧山,311200,浙江萧山人民医院药剂科 3. 杭州,310006,浙江医科大学药剂教研室 |
| 摘 要： | 目的：考察盐酸普鲁卡因的离子导入与电流强度、药物浓度的关系。方法：测定不同的电流强度、不同的药物浓度的离子导入增渗倍数（ＥＲ）。结果：固定药物浓度，电流强度为０．１，０．２和０．３ｍＡ时的ＥＲ值分别为６８．９９和１２７。固定电流强度０．２ｍＡ，药物浓度为０．０１５１，０．０３０４和０．０６０５ｇ／１００ｍｌ时的ＥＲ值分别为９５，９９和９８，结论：离子导入可以显著提高药物渗透速率，增渗倍数（ＥＲ）随 |
| 关 键 词： | 离子导入 盐酸普鲁卡因 增渗倍数 药物浓度 |
Study of iontophoresis of procaine hydrochloride |
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| Xu Donghang.Study of iontophoresis of procaine hydrochloride[J].The Chinese Journal of Modern Applied Pharmacy,1999,16(5):18-20. | |
| Authors: | Xu Donghang |
| Abstract: | OBJECTIVE:To investigate the effects of current intensity and drug concentration on iontophoresis of procaine hydrochloride.METHODS:The enhancing rates different current intensities and different concentration have been determined.RESULTS:When the current strength of iontophoresis is 0.1,0.2 and 0.3mA,the ERs are 68,99 and 127 respectively.Keeping the current strength constantly(0.2mA),the ERs are 95,99 and 98 when the donor concentration is 0.0151,0.0304 and 0.0605g/100ml respectively.CONCLUSION:Iontophoresis increased the flux of drug obviously.The enhancing rate(ER) correlated closely to the current intensity,but had is no relationship with drug concentration. |
| Keywords: | iontophoresis procaine hydrochloride enhancing rate current intensity drug concentration |
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