甲状腺功能亢进相关性肾损伤

甲状腺功能亢进(甲亢)是由体内甲状腺激素过多引起的一组临床综合征,其病理生理过程可累及多个器官.近年研究显示,甲亢可引起不同程度的肾脏损伤,这主要与机体的高代谢负荷,交感神经系统活性增强、自身免疫损伤、肾素-血管紧张素系统激活以及抗甲状腺药物毒性有关.在临床上,当甲亢患者出现蛋白尿或肾功能异常等肾损伤表现时,应警惕该病可能,可结合免疫学及病理学检查综合分析;一旦明确诊断,强调对甲亢本身的充分治疗,可联合血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂类药物或采取免疫干预治疗.

Hyperthyroidism-associated renal injury

Hyperthyroidism is the clinical syndrome that results from an excess of thyroid hormones,and its pathophysiologic process affects several organs.Recent data suggest that hyperthyroidism can induce renal injury in various degree,the mechanisms of which are associated with hish metabolism load,increased activity of sympathetic nervous system,autoimmune damage,activation of renin-augiotensin system and toxicity of antithyroid drug.Clinical workers should keep in mind of such a disease,especially when patients have proteinuria or other abnormal renal function.Immunological tests and renal biopsy can be used for diagnosis.Treatment of hyperthyroidism-associated renal injury includes restore of euthyroidism,utilization of ACEI/ARB drugs and immunologic intervention.