| 丹酚酸B对缺氧损伤心脏微血管内皮细胞细胞间粘附分子表达的影响 |
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| 引用本文： | 杜嵘,张伯礼,高秀梅,郭利平,张萌,刘洋,商洪才,王虹. 丹酚酸B对缺氧损伤心脏微血管内皮细胞细胞间粘附分子表达的影响[J]. 中国新药与临床杂志, 2004, 23(9): 616-618 |
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| 作者姓名： | 杜嵘 张伯礼 高秀梅 郭利平 张萌 刘洋 商洪才 王虹 |
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| 作者单位： | 1. 天津中医学院,天津,300193
2. 天津中医学院第一附属医院,天津,300193 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 目的 :探讨丹参有效成分丹酚酸B在心脏微血管内皮细胞 (CMEC)缺氧 /复氧损伤中的保护作用。方法 :通过心脏微血管内皮细胞体外培养技术 ,建立缺氧预适应 (HPC)模型并给予丹酚酸B ,应用酶联免疫方法检测细胞间粘附分子 1(ICAM 1)表达。结果 :在CMEC缺氧 3h ,复氧 6h后ICAM 1表达升高 ;缺氧预适应和应用丹酚酸B对CMEC进行预处理则能有效降低CMECICAM 1的表达。结论 :丹酚酸B在CMEC缺氧 /复氧损伤中可产生与缺氧预适应类似的保护效果。
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| 关 键 词： | 细胞低氧 细胞粘附分子 内皮,血管 心肌再灌注损伤 丹参 丹酚酸B |
| 文章编号： | 1007-7669(2004)09-0616-03 |
Effects of salveanolic acid B on expression of intercellular adhesion molecule- 1 on cardiac microvascular endothelial cells of hypoxia |
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| DU Rong,ZHANG Bo-li,GAO Xiu-mei,GUO Li-ping,ZHANG Meng,LIU Yang,SHANG Hong-cai,WANG Hong. Effects of salveanolic acid B on expression of intercellular adhesion molecule- 1 on cardiac microvascular endothelial cells of hypoxia[J]. Chinese Journal of New Drugs and Clinical Remedies, 2004, 23(9): 616-618 |
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| Authors: | DU Rong ZHANG Bo-li GAO Xiu-mei GUO Li-ping ZHANG Meng LIU Yang SHANG Hong-cai WANG Hong |
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| Affiliation: | DU Rong1,ZHANG Bo-li1,GAO Xiu-mei1,GUO Li-ping2,ZHANG Meng1,LIU Yang1,SHANG Hong-cai1,WANG Hong1 |
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| Abstract: | AIM: To investigate the protective effect of salveanolic acid B (Sal B) on cardiac microvascular endothelial cells (CMEC) injury after hypoxia and reoxygenation. METHODS: By the technique of cultivating CMEC in vitro, the damaging model of hypoxia preconditioning was established and Sal B was added. The expression of ICAM-1 was detected by ELISA. RESULTS: The expression of ICAM-1 of CMEC after hypoxia and reoxygenation is increased. The expression of ICAM-1 on CMEC could be reduced by hypoxia preconditioning and application of Sal B. CONCLUSION: The Sal B preconditioning can bring about the protective effect to CMEC injury after hypoxia and reoxygenation as same as that of ischemic preconditioning. |
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| Keywords: | cell hypoxia cell adhesion molecules endothelium vascular myocardial reperfusion injury salvia miltiorrhiza salvianolic acid B |
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