几种高脂血症动物模型的比较

为建立更合理而实用的高脂血症动物模型，比较了SD大鼠，Wistar大鼠和金黄地鼠的血清和肝脏脂质对高脂饲料的反应，大鼠高脂饲料配方为1％胆固醇，10％蛋黄粉和79％基础饲料，金黄地鼠高脂饲料配方为0．2％胆固醇，15％猪油和85％基础饲料，结果显示，经同脂饲料喂养5周后，SD大鼠，Wistar大鼠和金黄鼠高脂组血清甘油三酯水平分别比对照组高194．4％，和84．3％（P＜0．05），血清总胆固醇水平分别比组高76．8％，48．3％和134．8％（P＜0．05），提示金黄地鼠是一种良好的高胆固醇血症模型，而SD大鼠可能是一种较好的高甘油三酯血症模型。

Study on animal models for hyperlipidemia

To establish a better animal model for hyperlipidemia, three animal models with SD rats, Wistar rats and golden hamsters were explored. The semi purified diet for rats was composed of 1% cholesterol, 10% lard, 10% yolk powder and 79% normal diet. The semi purified diet for hamster was composed of 0.2% cholesterol, 15% lard and 85% normal diet. Serum TC, TG, HDL C, liver cholesterol and triglyceride were assayed. Serum TG of SD rat, Wistar rat and hamster was 194 4%, 86 2% and 84 3% respectively higher than that of control after 5 weeks of experiment. Serum TC of the three groups was 76 8%, 48 3% and 134 8% respectively higher than that of control. The results suggested that hamster might be a better animal model for hypercholesterolemia and SD rat might be better for hypertriglyceridemia.