V{beta}6-bearing T cells are involved in resistance to Trypanosoma cruzi infection in XID mice |
| |
Authors: | Silva, Anabela Cordeiro da Lima, Eduardo Cesar Santos Vicentelli, Marie-Helene Minoprio, Paola |
| |
Affiliation: | 1 Unité d'lmmunoparasitologie, CNRS, URA 1960, Departement d'lmmunologie, Institut Pasteur Paris, France 2 Faculdade de Farmácia da Universidade do Porto Portugal |
| |
Abstract: | BALB.xid mice, carrying an X-linked mutation leading to theabsence of CD5+ B cells, are highly resistant to Trypanosomacruzi Infection. These mice clear blood parasites In the acutephase of infection and do not develop the inflammatory Infiltrationcharacteristically observed in the chronic phase of susceptiblestrains of mice. We have shown that the resistance of BALB.xldIs dependent on the production of high levels of IFN-y. Natural(adoptive foster) or artificial (In vivo Injection of blockingantibodies) treatments of BALB.xld induced deletion of CD4+and CD8+ cells bearing Vß6 TCR. The absence of Vß6lymphocytes considerably reduced resistance to infection. Furthermore,in BALB.xld lacking this minor fraction of the T cell repertoire,almost 50% of the IFN-y production is lost. This indicates thatVß6-bearing T cells are either directly or Indirectlyinvolved in the production of IFN-y and, thus, important foran effective immune response during the acute phase of experimentalChagas' disease. |
| |
Keywords: | Chagas disease, Vß TCR, XID mice |
本文献已被 Oxford 等数据库收录! |
|