The Effect of Vitamin K and D Supplementation on Ovariectomy-Induced Bone Loss |
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Authors: | S Matsunaga H Ito T Sakou |
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Institution: | (1) Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890, Japan, JP |
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Abstract: | This study was designed to assess the effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Female
Sprague-Dawley rats aged 8–9 months were ovariectomized (OVX) or sham operated and divided into five experimental groups:
(1) ovariectomy (OVX), (2) OVX plus vitamin K supplementation, (3) OVX plus vitamin D supplementation, (4) OVX plus vitamin
K and vitamin D supplementation, and (5) sham operation. The trabecular bone area was estimated by bone histomorphometry by microradiography and histological examination. Bone loss in OVX plus
vitamin K and vitamin D group was significantly reduced at both 7 and 14 weeks compared with the OVX group. No significant
bone loss in OVX plus vitamin K or OVX plus vitamin D groups was found. A similar effect of vitamin K and D supplementation
on ovariectomy-induced bone loss was recognized in histological examination. Our findings indicate that vitamins K and D may
have a synergistic effect on reducing bone loss. This is valuable information for the treatment of bone loss in postmenopausal
women with osteoporosis.
Received: 1 September 1998 / Accepted: 10 January 1999 |
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Keywords: | : Ovariectomy — Microradiography — Menaquinone — Activated vitamin D3 |
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