TRH stimulation test in dementia of the Alzheimer type and elderly controls |
| |
| Authors: | T Sunderland P N Tariot E A Mueller P A Newhouse D L Murphy R M Cohen |
| |
| Affiliation: | 1. Trey Sunderland, M.D., Pierre N. Tariot, M.D., Edward A. Mueller, M.D., and Paul A. Newhouse, M.D. are Staff Psychiatrists, and Dennis L. Murphy, M.D., is Chief, Laboratory of Clinical Science, National Institute of Mental Health (NIMH), USA;2. Robert M. Cohen, M.D., Ph.D., is Chief, Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, NIMH, USA |
| |
| Abstract: | Dementia of the Alzheimer type (DAT) is known to be a heterogeneous syndrome with many clinical manifestations, including depression. In the present study, the thyrotropin-releasing hormone (TRH) stimulation test, previously used as a possible biological marker of depression, was administered to 15 DAT patients and 10 elderly controls. Seven out of 15 (47%) of the patients but none of the controls showed a blunted response with maximal changes of thyroid-stimulating hormone (TSH) from baseline of less than or equal to 7 microIU/ml following injection of 500 micrograms of TRH. The degree of blunting did not correlate with concurrent depression ratings. |
| |
| Keywords: | Dementia of the Alzheimer type depression thyrotropin-releasing hormone test |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
