| Rapid Inhibition of the Glutamate-induced Increase of Intracellular Free Calcium by Magnesium in Rat Hippocampal Neurons |
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| 引用本文： | 张蕲,胡波,孙圣刚,邓学军,梅元武,童萼塘. Rapid Inhibition of the Glutamate-induced Increase of Intracellular Free Calcium by Magnesium in Rat Hippocampal Neurons[J]. 华中科技大学学报(医学英德文版), 2004, 24(5): 424-426. DOI: 10.1007/BF02831098 |
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| 作者姓名： | 张蕲 胡波 孙圣刚 邓学军 梅元武 童萼塘 |
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| 作者单位： | Department of Phathophysiology，School of Basic Medical Sciences，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Neurology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Neurology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Neurology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Neurology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Neurology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China |
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| 摘 要： | Inrecentyears ,largenumbersofrelativestud iesonthemagnesium (Mg2 )andneurologicaldis easesverifiedinmanyneurologicaldiseases ,suchascerebrovasculardiseases,chronicalcoholpoisoning ,Wilsondiseaseetc .,wererelatedwiththeMg2 defi ciency .Magnesiumreagentsc…
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| 关 键 词： | [Ca^2＋]i Mg^2＋ Fura-2／AM |
| 收稿时间： | 2003-05-19 |
Rapid inhibition of the glutamate-induced increase of intracellular free calcium by magnesium in rat hippocampal neurons |
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| Zhang Qi,Hu Bo,Sun Shenggang,Deng Xuejun,Mei Yuanwu,Tong Etang. Rapid inhibition of the glutamate-induced increase of intracellular free calcium by magnesium in rat hippocampal neurons[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2004, 24(5): 424-426. DOI: 10.1007/BF02831098 |
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| Authors: | Zhang Qi Hu Bo Sun Shenggang Deng Xuejun Mei Yuanwu Tong Etang |
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| Affiliation: | 1. Department of Phathoph ysiology , School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China |
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| Abstract: | Summary By using Fura-2/AM, the effects of magnesium (Mg2+) on the glutamate-induced increase of intracellular free calcium ([Ca2+]i) in the cultured hippocampal neurons and the features were investigated by integrated photoelectric detecting system. The experiments were designed to three groups (The drug was spit to the cells for 20 s): Group A receiving 1×10−5 mol/L glutamate; Group B receiving 1×10−5 mol/L glutamate and 1×10−5 mol/L Mg2+ simultaneously; Group C receiving 1×10−5 mol/L glutamate again after [Ca2+]i in group B back to the baseline. The results showed that in group A, [Ca2+]i was obviously increased. In group B, the changes in [Ca2+] i and the peak value were significantly decreased. Moreover, the elevation of Phase 1 was slowed down and Phase 2 was shortened to some extent, and the plateau phase between them was relatively prolonged. In group C, calcium oscillation similar to that in group A occurred, but both the Phase 1 and Phase 2 were shortened and the Δ[Ca2+]i was slightly decreased. It was suggested that Mg2+ could quickly inhibit the rise of [Ca2+]i induced by glutamate in the cultured hippocampal neurons in rats. ZHANG Qi, male, born in 1963, M.D., Ph.D. |
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| Keywords: | magnesium glutamate intracellular free calcium |
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