急性胰腺炎发病机制和治疗的实验研究进展

在致病因素的作用下，各种消化酶和细胞因子、活性氧簇、内毒素、NF-κB等炎症介质的生成增加以及它们之间的相互作用，共同造成胰腺和远处器官的损伤。急性胰腺炎的治疗以一般治疗、抗氧化剂、生长抑素、糖皮质激素治疗为主，NBD多肽是研究的重点。

Advance on experimental study of pathogenesis andtreatment in acute pancreatitis

With the role of causative agent, the increase and interaction of various kinds of digestive enzymes and inflammation mediators such as cytokines, reactive oxygen species (ROS), endotoxin, NF-κB resulted in the injury of pancreas and distant organ. The treament of acute pancreatitis is based on general treatment, antioxidant, somatostatin and glucocorticoid. The NF-κB essential modifier binding domain peptide which is newly developed becomes the emphasis of treament research.