| 基质金属蛋白酶组织抑制因子-1基因多态性与慢性牙周炎相关性研究 |
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| 引用本文： | 彭文军,轩东英,赵红宇,张雪洋,王春先,赵华,章锦才. 基质金属蛋白酶组织抑制因子-1基因多态性与慢性牙周炎相关性研究[J]. 实用口腔医学杂志, 2009, 25(4). DOI: 10.3969/j.issn.1001-3733.2009.04.018 |
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| 作者姓名： | 彭文军 轩东英 赵红宇 张雪洋 王春先 赵华 章锦才 |
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| 作者单位： | 1. 郑州大学口腔医学院,450052
2. 广东省口腔医院·南方医科大学附属口腔医院 |
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| 基金项目： | 2007年度广东省医学科研基金资助项目 |
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| 摘 要： | 目的:探讨基质金属蛋白酶组织抑制因子-1(TIMP-1)基因多态性与慢性牙周炎易感性的相关性.方法:从广东汉族人群中收集70例慢性牙周炎(CP)患者及74 例牙周健康对照者的颊黏膜拭子,以Chelex-100法提取DNA,采用聚合酶链反应-限制性片段长度多态方法对TIMP-1 +372T/C(rs4898)、TIMP-1 +533C/T (rs1062849)多态性进行检测, χ2检验分析组间等位基因分布和基因型频率的差异.结果:TIMP-1 +372位C、T等位基因在CP组和对照组的分布差异无统计学意义(P=0.897,OR=1.062).TIMP-1 +533C/T多态性未检出.结论:TIMP-1 +372T/C多态性与中国广东汉族人慢性牙周炎的患病易感性无关,且该人群中不存在TIMP-1 +533C/T多态性.
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| 关 键 词： | 基质金属蛋白酶组织抑制因子 慢性牙周炎 单核苷酸多态性 等位基因 |
Correlation study of tissue inhibitor of matrix metalloproteinase-1 gene polymorphisms and chronic periodontitis |
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| PENG Wenjun,XUAN Dongying,ZHAO Hongyu,ZHANG Xueyang,WANG Chunxian,ZHAO Hua,ZHANG Jincai. Correlation study of tissue inhibitor of matrix metalloproteinase-1 gene polymorphisms and chronic periodontitis[J]. Journal of Practical Stomatology, 2009, 25(4). DOI: 10.3969/j.issn.1001-3733.2009.04.018 |
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| Authors: | PENG Wenjun XUAN Dongying ZHAO Hongyu ZHANG Xueyang WANG Chunxian ZHAO Hua ZHANG Jincai |
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| Abstract: | Objective: To investigate the relationship between TIMP-1 gene polymorphisms and susceptibility of chronic periodontitis(CP) in Han Cantonese. Methods: Buccal swabs from 70 CP patients and 74 periodontal healthy controls were collected. DNA was extracted from these buccal swabs by using Chelex-100. TIMP-1 +372T/C (rs4898)、TIMP-1+533C/T (rs1062849) polymorphisms were tested by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP). Allele distribution and genotypes frequencies in the patients and controls were analyzed. Results: Frequency variance of allele T and C at site of TIMP-1 +372 in patients and controls showed no statistical difference. TIMP-1+533C/T polymorphism of TIMP-1 hadn't been found in the present study. Conclusion: There is no relationship between TIMP-1 +372T/C polymorphism and susceptibility of chronic periodontitis, and TIMP-1 +533C/T polymorphism doesn' t exist among Han Cantonese. |
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| Keywords: | Tissue inhibitor of matrix metalloproteinase Chronic periodontitis Single nucleotide polymorphism Allele |
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