The sensitivity of rat spinal interneurones and Renshaw cells to L-glutamate and L-aspartate |
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| Authors: | T. J. Biscoe P. M. Headley D. Lodge M. R. Martin J. C. Watkins |
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| Affiliation: | (1) Department of Physiology, The Medical School, University of Bristol, BS8 lTD Bristol, England;(2) Present address: Department of Pharmacology, John Curtin School of Medical Research, Canberra, Australia |
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| Abstract: | Summary L-Glutamate and L-aspartate were administered electrophoretically near spinal interneurones and Renshaw cells of pentobarbitone-anaesthetized rats. Other spinal interneurones were consistently more sensitive to L-glutamate than to L-aspartate. Renshaw cells, however, showed no consistent difference in their sensitivity to these two amino acids. The results, which are compared with those reported previously in the cat, support the hypothesis that L-glutamate could be a transmitter at spinal primary afferent terminals.Wellcome Trust Research Training Scholar.Animal Health Trust/Wellcome Trust Research Fellow. |
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| Keywords: | Spinal interneurones Renshaw cells L-Aspartate L-Glutamate |
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