长沙地区淋球菌流行株的药物敏感性检测

目的：了解长沙地区淋球菌流行株对抗菌药物的敏感性，为淋病的防治提供实验依据。方法：改良碘量法检测β－内酰胺酶，纸片扩散法检测86株淋球菌对9种抗菌药物的敏感性。结果：质粒介导的产青霉素酶淋球菌（PPNG）和质粒介导的高度耐四环素淋球菌（TRNG）分别为35株（40.69%)和20株（23.26%)。在测定的9种抗菌药物中，淋球菌耐药性较高的依次为四环素、头孢美唑、青霉素、环丙沙星、氧氟沙星，耐药率分别为45.35%，50.00％，62.79%，77.91%，87.21%。而敏感性较高的4种抗菌药物依次为头孢呋辛、头孢三嗪、头孢吡肟、壮观霉素，敏感率分别为77.91%,80.23%,86.05%,98.84%。结论：青霉素、四环素以及氟喹诺在药物已不宜作为长沙地区治疗淋病的常规药物；壮观霉素可作为治疗淋病的首选药物，但已出现耐药菌株，应当引起高度警惕。

Antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha]

OBJECTIVE: To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha and to provide a reference for the prevention and treatment of gonorrhea. METHODS: beta-Lactamase was determined by a modified iodometric method and the susceptibility to 9 antibiotic agents was tested by the disc diffusion method in 86 isolates. RESULTS: Plasmid-mediated penicillinase-producing Neisseria gonorrhoeae and plasmid-mediated tetracycline-resistant Neisseria gonorrhoeae were 40.69% and 23.26%, respectively. Of all the 9 antibiotic agents, tetracycline, cefmetazole, penicillin, ciprofloxacin, and ofloxacin had a higher resistance and the percentages of resistance were 45.35%, 50.00%, 62.79%, 77.91%, and 87.21%, respectively. On the other hand, cefuroxime, ceftriaxone, cefepime, and spectinomycin had a higher susceptibility and the percentages of susceptibility were 77.91%, 80.23%, 86.05%, and 98.84%, respectively. CONCLUSION: Penicillin, tetracycline and fluoroquinolone can not be used as routine agents to cure gonorrhea; and spectinomycin can be used as primary medicine to cure gonorrhea in Changsha, but clinical doctors need to pay more attention to it because resistant strains have come into existence.