LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse |
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| Authors: | May Alarab Maria AT Bortolini Harold Drutz Stephen Lye Oksana Shynlova |
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| Affiliation: | (1) Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, 700 University Avenue, Suite 3083, Toronto, ON, M5G 1Z5, Canada;(2) Department of Obstetrics and Gynecology, University of Toronto, Toronto, M5S 1A1, Canada;(3) Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, Canada |
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| Abstract: | Introduction and Hypothesis The extracellular matrix proteins collagen and elastin provide tissue strength and resilience, whereas lysyl oxidase enzymes play a major role in their stabilization. This study examines the expression and tissue localization of lysyl oxidase family proteins in the anterior vaginal wall of premenopausal women with advanced pelvic organ prolapse (POP, n = 15) and asymptomatic controls (n = 11). All women were in the proliferative phase of menstrual cycle. |
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