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Surveillance of active human cytomegalovirus infection in hematopoietic stem cell transplantation (HLA sibling identical donor): search for optimal cutoff value by real-time PCR |
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| Authors: | Renata MB Peres Cláudia RC Costa Paula D Andrade Sandra HA Bonon Dulcinéia M Albuquerque Cristiane de Oliveira Afonso C Vigorito Francisco JP Aranha Cármino A de Souza Sandra CB Costa |
| Affiliation: | (1) Department of Clinical Medicine, Faculty of Medical Sciences, University of Campinas - Unicamp, P.O.Box 6111, Zipe Code 13083-970 Campinas, SP, Brazil;(2) Bone Marrow Transplant Unit, Hemocenter, Faculty of Medical Sciences, University of Campinas - Unicamp, P.O.Box 6111, Zipe Code 13083-970 Campinas, SP, Brazil |
| Abstract: | BackgroundHuman cytomegalovirus (CMV) infection still causes significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Therefore, it is extremely important to diagnosis and monitor active CMV infection in HSCT patients, defining the CMV DNA levels of virus replication that warrant intervention with antiviral agents in order to accurately prevent CMV disease and further related complications. |
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