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Proton pump inhibitor step-down therapy for GERD: a multi-center study in Japan |
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| Authors: | Tsuzuki Takao Okada Hiroyuki Kawahara Yoshiro Takenaka Ryuta Nasu Junichiro Ishioka Hidehiko Fujiwara Akiko Yoshinaga Fumiya Yamamoto Kazuhide |
| Affiliation: | Takao Tsuzuki,Hiroyuki Okada,Yoshiro Kawahara,Junichiro Nasu,Kazuhide Yamamoto,Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine,Dentistry,and Pharmaceutical Sciences,Okayama 700-8558,Japan Ryuta Takenaka,Department of Internal Medicine,Tsuyama Central Hospital,Okayama 708-0841,Japan Hidehiko Ishioka,Ishioka clinic,Hiroshima 721-0926,Japan Akiko Fujiwara,Okayama Saiseikai General Hospital,Okayama 700-8511,Japan Fumiya Yoshinaga,Depar... |
| Abstract: | AIM:To investigate the predictors of success in stepdown of proton pump inhibitor and to assess the quality of life(QOL).METHODS:Patients who had heartburn twice a week or more were treated with 20 mg omeprazole(OPZ) once daily for 8 wk as an initial therapy(study 1).Patients whose heartburn decreased to once a week or less at the end of the initial therapy were enrolled in study 2 and treated with 10 mg OPZ as maintenance therapy for an additional 6 mo(study 2).QOL was in-vestigated using the gastrointesti... |
| Keywords: | Gastroesophageal reflux disease Proton pump inhibitor Omeprazole Step-down therapy Gastrointestinal symptom rating scale |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ | |