白介素-2,白介素-13与输卵管粘膜上皮炎的相关性研究

目的探讨血清炎症因子白细胞介素-2（IL-2）,白细胞介素-13（IL-13）与输卵管粘膜上皮炎的关系。方法运用免疫组化结合病理图像半定量分析方法,检测30例输卵管粘膜上皮炎壶腹部标本（研究组）,30例正常输卵管壶腹部标本（对照组）的表达情况。结果IL-2在研究组输卵管粘膜中阳性表达与对照组比较,有升高趋势,但两组比较无统计学意义（P〉0.05）;IL-13在研究组输卵管粘膜中阳性表达高于对照组,两组比较有统计学差异（P〈0.05）;研究组输卵管炎患者粘膜上皮局部IL-2/IL-13显著下降（P〈0.05）。结论输卵管慢性炎会引起IL-2,IL-13表达增强,IL-2/IL-13比值下降提示可能出现TH1/TH2细胞的免疫功能失衡。

Relationship salpingitis and the expression of interleukine-2.interleukine-13 in mucous epithelium of Fallopian tube

Obejective： To explore interleukine -2 （IL- 2）, IL- 13 possible mechanisms in mucous epithelium of fallopian tuble. Method： Ampulla of 30 chronic salpingitis （study group）, 30 normal fallopian tube （control group） were selected. Immunohistochemistry and semi -quantity pathologic image software of IL -2, IL - 13 respectively. Results： No significant difference was found for IL - 2 expression between study group and control group （ P 〉 0. 05）, while it was higher in study group than in control group ; The expression of IL - 13 was higher in study group than in control group, and significant difference was found （ P 〈0. 05） ; The ratio of IL -2/IL - 13 was significantly lower than control group in study group （ P 〈0. 05） . Conclusions： The higher expression of IL-2, IL- 13 probably participated in the formation of chronic inflammation of fallopian tube . TH1/TH2may be inbalance in mucous epithelium of fallopian tube pationents.