Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis |
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Authors: | Celik Atac Ozcetin Mustafa Celikyay Zekiye Ruken Yuksekkaya Sogut Erkan Yerli Yasemin Kadi Hasan Koc Fatih Damar Ibrahim Halil Ceyhan Koksal Erkorkmaz Unal |
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Affiliation: | Gaziosmanpasa University, Faculty of Medicine, Department of Cardiology, Tokat, Turkey. dretaci@yahoo.com |
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Abstract: | ObjectiveTo evaluate possible subclinical atherosclerosis using biomarkers and ultrasound-guided methods in a group of adolescents having fathers with premature atherosclerosis.MethodsThirty-three subjects whose fathers had a history of premature coronary artery disease and 30 counterparts whose fathers had no history of coronary artery disease were included in the study.ResultsThe homocysteine levels, high-sensitivity C-reactive protein levels, and cardiac chamber sizes and functions did not differ between the two groups. The carotid stiffness index β (CSI), the intima-media thickness (CIMT) and aortic pulse wave velocity (PWV) values were higher in the group with a family history of coronary artery disease, but only the difference in the CSI was statistically significant (CSI 3.07 ± 1.33 vs 3.88 ± 1.25, P = 0.015; CIMT 0.53 ± 0.09 mm vs 0.57 ± 0.08 mm, P = 0.068; PWV 3.49 ± 0.53 m/s vs 3.78 ± 0.63 m/s, P = 0.053).ConclusionAmong several markers of subclinical atherosclerosis, the CSI was significantly higher in adolescents who had a family history of premature atherosclerosis. The small sample size, the multifactorial nature of atherosclerosis or the insufficient power of these methods may explain these results. |
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