TGF-β1/Smad3信号转导通路与创伤后瘢痕形成

目的对近年TGF-β1/Smad3信号转导通路与创伤后瘢痕形成的相关研究作一综述。方法广泛查阅国内外近年有关TGF-β1/Smad3信号转导通路及与创伤后瘢痕形成的文献,并进行综述。结果 TGF-β1是纤维化疾病的重要影响因子,通过TGF-β1/Smad3信号通路转导产生其生物学效应。该途径受多种因子调控并在细胞及分子水平与其他信号通路串话。该途径参与创伤后早期炎性反应、创面愈合及后期病理性瘢痕的形成。在分子水平干预转导途径的各个环节,可以影响纤维化及细胞外基质沉着的进程。结论 TGF-β1/Smad3信号转导途径是影响创伤后瘢痕形成及细胞外基质沉着的重要途径。对该途径进行深入研究,可为临床促进创面的愈合及病理性瘢痕的防治奠定理论基础。

Transforming growth factor beta1/Smad3 signal transduction pathway and post-traumatic scar formation

Objective To summarize the recent progress in related research on transforming growth factor β1(TGF-β1)/Smad3 signal transduction pathway and post-traumatic scar formation.Methods Recent related literature at home and abroad on TGF-β1/Smad3 signal transduction pathway and post-traumatic scar formation was reviewed and summarized.Results TGF-β1 is an important influence factor of fibrotic diseases,and it plays biological effects by TGF-β1/Smad3 signal transduction pathway.The pathway is regulated by many factors and has crosstalk with other signal pathways at cellular and molecular levels.The pathway is involved in the early post-traumatic inflammatory response,wound healing,and late pathological scar formation.Intervening the transduction pathway at the molecular level can influence the process of fibrosis and extracellular matrix deposition.Conclusion TGF-β1/Smad3 signal transduction pathway is an important way to affect post-traumatic scar formation and extracellular matrix deposition.The further study on the pathway will provide a theoretical basis for promotion of wound healing,as well as prevention and treatment of pathological scar formation.