塞来昔布致急性胰腺炎

1例43岁女性患者因肩周炎服用塞来昔布胶囊0．2g，2次／d，共服用2周。末次服药后2h上腹出现持续性钝痛，伴腹胀、恶心、呕吐。实验室检查示血清淀粉酶1822U／L，胰淀粉酶1529U／L，脂肪酶1410U／L，白细胞计数12．7×10^9／L，中性粒细胞0．74，淋巴细胞0．16。腹部超声检查和磁共振胰胆管造影示胰腺弥漫性增大、胰腺周围有液性渗出，诊断为急性胰腺炎。停用塞来昔布，禁食，给予营养支持和抑酶、抑酸、抗感染治疗13d，患者腹痛、腹胀消失，实验室检查示淀粉酶86U／L，胰淀粉酶48U／L，脂肪酶55U／L，白细胞计数7．2×10^9／L，中性粒细胞0．65，淋巴细胞0．32。胰腺CT示胰头、胰体和胰尾位于同一层面，形态及大小基本正常。

Acute pancreatitis due to celecoxib

A 43-year-old woman with scapulohumeral periarthritis received celecoxib 0.2 mg twice daily for 2 weeks. She developed upper abdominal persistent dull pain, distension, nausea and vomiting two hours after the last administration. Laboratory tests showed the following values： serum amylase 1 822 U/L, amylopsin 1 529 U/L, lipase 1 410 U/L, white blood cell count 12.7 x 10^9/L, neutrophils 0.74, and lym phocytes 0. 16. Abdominal ultrasound examination and magnetic resonance cholangiopancreatography showed a diffusely enlarged pancreas and fluid exudation around pancreas. The patient was diagnosed as acute pancreatitis. Celecoxib was withdrawn. Thirteen days after the therapy with jejunitas, nutritional supporting, enzyme inhibition, acid suppression, and anti-infection, her symptoms of abdominal pain and distension were disappeared. Laboratory tests showed the following values ： serum amylase 86 U/L, amylopsin 48 U/L, lipase 55 U/L, white blood cell count 7.2x 10^9/L, neutrophils 0.65, and lymphocytes 0.32. Abdominal CT showed caputpancreatis, corpora pancreatic, and pancreatic tail were located on the same level, the oancreatic shaoe and size were normal.