| 雷公藤多苷致闭经 |
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| 引用本文： | 路敏,周颖,崔一民,白文佩. 雷公藤多苷致闭经[J]. 药物不良反应杂志, 2014, 0(3): 177-178 |
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| 作者姓名： | 路敏 周颖 崔一民 白文佩 |
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| 作者单位： | [1]北京大学第一医院药剂科,100034 [2]北京大学第一医院妇产科,100034 |
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| 摘 要： | 1例41岁女性患者因肾小球肾炎、肾性高血压给予雷公藤多苷（20 mg，3次/d）、泼尼松（20 mg，1次/d）、缬沙坦（80 mg，1次/d）、苯磺酸氨氯地平（5 mg，1次/d）、碳酸钙（750 mg，3次/d）和骨化三醇（0.25μg，1次/d）口服。治疗1个多月后，患者因月经未来潮停用雷公藤多苷和泼尼松，但停药后月经仍未来潮，共闭经5个月。性激素检查：黄体生成激素29 U/L；卵泡刺激素7 U/L；雌二醇1168 pmol/L；催乳激素0.02 nmol/L；睾酮0.12 nmol/L；孕酮1.5 nmol/L。给予性激素地屈孕酮10 mg，2次/d口服治疗，连用10 d。停用地屈孕酮后第4天月经来潮，持续5 d。此后患者恢复正常月经周期。
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| 关 键 词： | 雷公藤 闭经 激素替代疗法 |
Tripterygium glycosides-induced amenorrhea |
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| Lu Min,Zhou Ying,Cui Yimin,Bai Wenpei. Tripterygium glycosides-induced amenorrhea[J]. Adverse Drug Reactions Journal, 2014, 0(3): 177-178 |
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| Authors: | Lu Min Zhou Ying Cui Yimin Bai Wenpei |
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| Affiliation: | .( Department of Pharmacy, Peking University First Hospital, Beijing 100034, China) |
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| Abstract: | A 41-year-old female patient received tripterygium glycosides 20 mg thrice daily, prednisone 20 mg once daily,valsartan 80 mg once daily,amlodipine besylate 5 mg once daily,calcium carbonate 750 mg thrice daily and calcitriol 0. 25 μg once daily for glomerulonephritis and renal hypertension. Tripterygium glycosides and prednisone had to discontinue because the patients developed amenorrhea about one month after the therapy,and amenorrhea has lasted for five months. The sex hormone levels were measured as follows：luteinizing hormone 29 U/L,follicle-stimulating hormone 7 U/L,estradiol 1 168 pmol/L,prolactin 0. 02 nmol/L,testosterone 0. 12 nmol/L;progesterone 1. 5 nmol/L. Hormone replacement therapy with dydrogesterone 10 mg twice daily for 10 days was given. Her menstruation started on day 4 after dydrogesterone discontinuation and lasted for 5 days. The regular menstrual cycle has been restored. |
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| Keywords: | Tripterygium wilfordii Amenorrhea Hormone replacement therapy |
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