咳嗽变异性哮喘患者血浆甲状腺激素含量研究简

目的 探讨咳嗽变异性哮喘（CVA）患者急性加重期及缓解期血浆甲状腺激素含量变化及其临床意义.方法 应用电化学发光法测定48例CVA患者急性加重期和缓解期及35 例健康志愿者血浆三碘甲状腺原氨酸（TT3）、甲状腺素（TT4）、促甲状腺素（TSH）、血浆三碘游离甲状腺素（FT3）和游离甲状腺素（FT4）的含量.同时检测动脉血中氧分压（PaO2）,并分析CVA患者缺氧程度与甲状腺激素水平的相关性.结果 CVA急性加重期和缓解期TT3 、FT3、FT4含量与对照组相比明显降低（P〈0.01,P〈0.05）;CVA患者急性加重期TT3、FT3和FT4含量显著低于缓解期（P〈0.05）.CVA患者急性发作期血浆TT3、FT3、FT4水平与氧分压（PaO2）呈显著的正相关.结论 CVA患者血浆TT3、FT3、FT4 水平明显低于正常人,缺氧是导致CVA患者甲状腺激素含量变化的重要因素之一.

Clinical significance of altered thyroid hormone level in patients with cough variant asthma

Objective To investigate the change of thyroid hormone level in patients with cough variant asth-ma （CVA） and to explore its clinical significance. Methods Serum total triiodothyronine （ TT3 ）, total thyroxine （TT4 ）, thyroid-stimulating hormone （ TSH）, free triiodothyronine （ FT3 ） and free thyroxine （ FT4 ） levels were ana lyzed by electro chemil in 48 cough variant asthma patients and 35 healthy controls. Partial pressure ofarterial oxygen （PaO2 ） and its correlation with thyroid hormone level were also detected. Results The levels of TF3 , FT3 and FT4 in the acute exacerbation group and the remission group were much lower than that in the controls （P 〈 0. 01, P 〈 0. 05 respectively）, and the acute exacerbation group was much lower than the remission group （P 〈 0. 05）. Serum TF3 , FT3 and FT4 levels were positively correlated with PaO2. Conclusion The results above indi cate that the serum levels of TI3 , FT3 and FT4 in CVA patients are lower than those in the healthy controls, and hy poxia may be an important factor causing the altered thyroid hmnone level.