浙江省台州地区６０１４例女性宫颈人乳头瘤病毒感染情况及流行病学分析

摘要：目的　了解浙江台州地区女性宫颈人乳头瘤病毒（ＨＰＶ）感染率以及基因亚型的分布特征。方法　
采用液相芯片技术对浙江省台州医院妇科门诊就诊患者的宫颈脱落细胞共６０１４例进行ＨＰＶ 基因分型检
测，并对该地区女性ＨＰＶ 感染率、基因亚型分布等进行分析。采用ＳＰＳＳ１６．０软件对所得资料进行统计，
组间率的比较用χ
２ 检验，犘＜０．０５ 为差异有统计学意义。结果　浙江台州地区女性ＨＰＶ 总感染率为
２２．１５％（１３３２／６０１４），单一型感染率为１６．５３％ （９９４／６０１４），多重感染率为５．６２％ （３３８／６０１４）。ＨＰＶ
阳性患者中高危型ＨＰＶ 感染次数占８６．０１％ （１５３７／１７８７），感染率从高到低依次为ＨＰＶ５２ （１７．８０％）、
ＨＰＶ１６ （１１．８６％）、ＨＰＶ５８ （１０．２４％）、ＨＰＶ５６ （５．７４％） 和ＨＰＶ１８ （５．５４％）。５１～６０ 岁组感染率
（２９．５８％）与总感染率（２２．１５％）比较差异有统计学意义（犘＜０．０５），且不同年龄组女性宫颈ＨＰＶ 感染
各亚型分布情况差异有统计学意义。结论　浙江省台州地区女性ＨＰＶ 感染率较高，且以高危型ＨＰＶ５２、
１６、５８感染为主，要重视老年妇女的高危型ＨＰＶ 感染。
关键词：人乳头瘤病毒；基因分型；宫颈；流行病学
中图分类号：Ｒ３７３　　文献标识码：Ａ　　文章编号：１００９ ６６３９ （２０１４）０４ ０３０９ ０５

Epidemiological features of cervical human papilloma virus infection among 6014 women in Taizhou

Objective To understand the epidemiological features of cervical human papilloma virus（HPV）infection in women in Taizhou. Methods A total of 6 014samples of cervical smear collected from female outpatients visited gynecologic clinics in Taizhou hospital for the identification of HPV genotype by using xMAP of Luminex 200TM as well as to analyze the infection rate and the distribution of HPV genotypes.All statistical analyses were performed under SPSS 16.0.Chi-square test was used to analyze data. Results The overall prevalence of HPV infection was 22.15%（1 332/6 014）with 16.53%（994/6 014）of single infection and5.62%（338/6 014）of co-infection.Among HPV positive patients,86.01%（1 537/1 787）was found to be high-risk infection.HPV 52was identified as the most prevalent genotype（17.80%）,followed by HPV16（11.86%）,HPV58（10.24%）,HPV56（5.74%）and HPV18（5.54%）.The infection rate was the highest among women aged 51-60years which had significant difference compared with the total infection rate（29.58%vs 22.15%）（P＆lt;0.05）.Also,the genotype was different among female age groups. Conclusions This study provides baseline data on HPV prevalence among women in Taizhou of Zhejiang province,China.Low prevalence of HPV vaccine types and relatively high prevalence of HPV52,HPV16and HPV58are observed,indicating that high-risk types of HPV infection among older women need to be under surveillance.