Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells |
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Authors: | Nakamura Hiroyuki Mukai Mutsuko Komatsu Keiko Tanaka-Okamoto Miki Itoh Yu Ishizaki Hiroyoshi Tatsuta Masaharu Inoue Masahiro Miyoshi Jun |
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Affiliation: | Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan. nakamura-hi@mc.pref.osaka.jp |
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Abstract: | We have previously shown that transforming growth factor-beta1 (TGF-beta1) markedly stimulates the invasive capacity of rat ascites hepatoma AH130 W1 cells in vitro and in vivo. A differential hybridization procedure was used to isolate genes that were specifically up-regulated in TGF-beta1 treated W1 cells. Among ten independent cDNA clones, we focused on LMO7 and a variant isoform, LMO7S, that was generated by alternative splicing. LMO7 had PDZ and LIM domains, while LMO7S had only PDZ domain. TGF-beta1 up-regulated expression levels of LMO7 and LMO7S. LMO7 expression was up-regulated in the highly metastatic clone MM1. |
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