| 新生大鼠缺氧缺血性脑损伤细胞退行性变方式的超微结构研究 |
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| 引用本文： | 章韵,王自能,苗竹林.新生大鼠缺氧缺血性脑损伤细胞退行性变方式的超微结构研究[J].陕西医学杂志,2005,34(1):7-10. |
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| 作者姓名： | 章韵 王自能 苗竹林 |
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| 作者单位： | 暨南大学附属第一医院围产医学中心,广州,510632 |
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| 摘 要： | 目的 :研究新生大鼠缺氧缺血性脑损伤后脑细胞退行性变方式。方法 :对 7日龄 SD大鼠采用左侧颈总动脉永久性结扎联合 7.7%低氧吸入 1 h复制模型。分别在复氧后4h,2 4 h,72 h,1周取材 ,利用电镜技术观察颈总动脉结扎侧海马皮质部神经元的超微结构。结果 :神经元退行性变形式包括坏死、杂合体、凋亡、脂性退变及暗细胞。结论 :新生大鼠缺氧缺血性脑损伤神经元退行性变形式多样。
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| 关 键 词： | 缺氧缺血 脑/并发症 颅脑损伤/病理学 神经变性疾病/病理学 细胞/超微结构 大鼠 |
Ultrastructural study on the neuron degeneration forms of hypoxic-ischemic encephalopathy in neonatal rats |
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| Center of Perinatology,the First Affiliated Hospital of Jinan University.Ultrastructural study on the neuron degeneration forms of hypoxic-ischemic encephalopathy in neonatal rats[J].Shaanxi Medical Journal,2005,34(1):7-10. |
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| Authors: | Center of Perinatology the First Affiliated Hospital of Jinan University |
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| Institution: | Guangzhou 510632 |
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| Abstract: | Objective:To investigate the neuron degeneration of hypoxic-ischemic encephalopathy(HIE) in neonatal rat. Methods: HIE of 7d rat pups was induced by ligation of the arteria carotis communis sinistra and inhalation of 7.7% oxygen at 36℃ for 1h. The left hippocampus cerebral cortex was removed at different recovery time points(4h,24h,72h,1week), and their ultrastructure was investigated electro-microscopically. Results: morphologically, The neuron degeneration of HIE could be classified as classic apoptotic phenotype, hybrid phenotype, lipid degeneration phenotype, classic necrotic phenotype, dark cell phenotype. Conclusion: This neuron degeneration of HIE in neonatal rats displayed a morphological diversity. |
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| Keywords: | Hypoxia-ischemia brain/complications Craniocerebral trauma/pathology Neurodegenerative diseases/pathology Cells/ultrastructure Rats |
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