T cell subsets and cellular immunity in end-stage renal disease |
| |
Authors: | K Raska J Raskova S M Shea R M Frankel R H Wood J Lifter I Ghobrial R P Eisinger L Homer |
| |
Affiliation: | Piscataway, New Jersey, USA;Raritan, New Jersey, USA;New Brunswick, New Jersey, USA;Perth Amboy, New Jersey, USA |
| |
Abstract: | The T lymphocyte population was studied by immunofluorescent staining with monoclonal antibodies and laser flow cytometry in the blood of 50 patients with end-stage renal disease undergoing long-term maintenance intermittent hemodialysis. The absolute number of T cells was lower in patients receiving dialysis for more than one year (p less than 0.001), as was the absolute count of helper T cells (p less than 0.005). In patients under 30 years of age, the absolute number of helper T cells was markedly reduced, whereas the number of suppressor/cytotoxic T lymphocytes was not changed. In patients between the ages of 30 and 60 years, both helper and suppressor cells were significantly reduced. In patients over 60 years of age, only the number of helper T cells was reduced. The in vitro response of patients' lymphocytes was reduced both in the mixed lymphocyte reaction (p less than 0.01) and after phytohemagglutinin stimulation (p less than 0.001). Natural killer cytotoxicity of patients' peripheral blood mononuclear cells, however, was unaffected. |
| |
Keywords: | Requests for reprints should be addressed to Dr. Karel Raska Jr. Department of Pathology UMDNJ-Rutgers Medical School PO Box 101 Piscataway New Jersey 08854. |
本文献已被 ScienceDirect 等数据库收录! |
|