| 元胡止痛分散片的制备工艺研究 |
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| 引用本文： | 苏乐群,顾卫平,张曼红,黄欣.元胡止痛分散片的制备工艺研究[J].中成药,2006,28(10):1417-1420. |
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| 作者姓名： | 苏乐群 顾卫平 张曼红 黄欣 |
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| 作者单位： | 1. 山东省千佛山医院,山东,济南,250014
2. 山东医药工业研究所,山东,济南,250100 |
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| 摘 要： | 目的:制备元胡止痛分散片(延胡索,白芷)。方法:采用单因素试验及U9(94)均匀设计试验以多个指标考察分散片的处方和制备工艺。结果:采用优化条件选择分散片片重为400 mg/片,淀粉34%、微晶纤维素40%、乳糖10%作为填充剂,8%的交联羧甲基纤维素钠(cCMC-Na)为崩解剂,15%PVPK30的乙醇溶液为黏合剂。结论:所制分散片处方合理、工艺可行,溶出快。
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| 关 键 词： | 元胡止痛分散片 制备 工艺研究 |
| 文章编号： | 1001-1528（2006）10-1417-03 |
| 收稿时间： | 06 11 2005 12:00AM |
| 修稿时间： | 2005-06-11 |
The preparation of Yuanhuzhitong Dispersible Tablet |
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| SU Le-qun,GU Wei-ping,ZHANG Man-hong,HUANG Xin.The preparation of Yuanhuzhitong Dispersible Tablet[J].Chinese Traditional Patent Medicine,2006,28(10):1417-1420. |
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| Authors: | SU Le-qun GU Wei-ping ZHANG Man-hong HUANG Xin |
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| Institution: | 1. Qianfoshan Hospital, Shandong Province, Jinan 250012, China; 2. Shandong Provincial Institute of Pharmaceutical Industry, Jinan 250100, China |
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| Abstract: | AIM: To prepare Yuanhuzhitong Dispersible Tablet.(Rhizoma corydalis,Radix Angeliae Dahuricae) METHODS: To inspect formula and preparation technology of dispersible tablet using monofactor experiment and U_9(9~4) uniform design experiment on the basis of multi-markers. RESULTS: The weight of dispersible tablet was definited as 400 mg,the pharmaceutical adjuvants were 34% starch,40% MCC and 10% lactose as filler,8% cCMC-Na as disintegrat,15% PVPK_(30) alcohol water blend as adhesive on the basis of mono-factor test.(CONCLUSION): The formula is reasonable and technology is feasible. |
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| Keywords: | Yuanhuzhitong Dispersible Tablet preparation technology |
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