pH-dependent geometric isomerization of roxithromycin in simulated gastrointestinal fluids and in rats |
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| Authors: | Zhang Shuqiu Xing Jie Zhong Dafang |
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| Affiliation: | Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110015, People's Republic of China. |
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| Abstract: | The biotransformation of roxithromycin in simulated gastrointestinal fluids at 37 degrees C and in rats was investigated by using liquid chromatography-tandem mass spectrometry. Roxithromycin degraded to its Z-isomer and decladinose derivative in simulated gastrointestinal fluids in vitro at pH
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