婴幼儿轮状病毒肠炎肠道外多器官损害的临床研究

目的 探讨婴幼儿ＨＲＶ肠炎患儿肠道外多器官损害状况及其与预后的关系。方法 采用前瞻性调查方法，对１２０例ＨＲＶ肠炎患儿呼吸、心、肝、肾、脑及胰的临床损害及其与预后的关系进行分析。结果（1）HRV肠炎的肠道道外器官损害中，1个器官损害发生率为18.33%（22/120），2个器官损害的发生率为45.83%(55/120），3个器官损害的发生率为12.50%(15/120)。4个器官损害的发生率为11.66%(14/120）；（2）HRV肠炎的肠道外器官损害中，以呼吸系统最多，占88.33%(106/120)，其次是心脏，占65,83%(79/120），肝、肾分别为24.16%(29/120)和12.50%(15/120)，胰、脑占的比例最少，分别为3.33%(4/120)和2.50%(3/120);（3）肠道外器官损害多随腹泻症状的好转而逐渐恢复正常。结论 （1）HRV肠炎的肠道外多器官损害拓临床上比较多见，并以2个器官损害的发生率最多；（2）HRV肠炎的肠道外器官损害中，以呼吸系统最多，提示HRV肠炎患儿可能先有呼吸系统感染，后经血行播散到肠道及身体其他器官；（3）HRV腹泻患儿的肠道外损害多数症状轻微，为一过性损害，很少引起严重后果。

Clinical Study of Infantile Rotavirus Enteritis Complicated with Multiple Organ Injury

Objective　To investigate the relationship between multiple organ injury and the prognosis in infantile rotavirus enteritis.Methods　We made a prospective study on 120 cases of infantile rotavirus enteritis,evaluated the parenteral organs involvement in all the cases and analysed the relationship of multiple organ injury and the prognosis.Results　①In these patients,one organ involvement rate of infantile rotavirus enteritis was 18.33%(22 of 120 cases),two organ involvement rate was 45.83% (55 of 120 cases),three organ involvement rate was 12.50%(15 of 120 cases) and four organ involvement rate was 11.66%(12 of 120 cases).②In the patients,88.33%(106 of 120 cases) of the cases had respiratory system injury,cardiac injury was in the second place (65.82%,79 of 120 cases).The hepatic and renal involvement rate was 24.16%(29 of 120 cases) and 12.50%(15 of 120 cases) respectively.Only 3.33% and 2.50% of the cases had pancreas and encephalon injury.③With the symptoms of enteritis disappeared,all the involved organs gradually recovered.Conclusions　①Multiple organ injury is very common in infantile rotavirus enteritis and two organs involvement rate is in the first place.②Among all the injured organs,respiratory organ is the most common involved organ,which indicates that the patients perhaps have respiratory infection firstly,and then the rotavirus transmits to the intestine and the other organs through the blood circulation.③Most of the infant with parenteral organ injury have mild symptoms.The organ dysfunctions are all transitory,which do not lead to serious consequences.