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Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure
Authors:Mustafa Turgut Yıldızgören  Türkan Nadir Öziş  Ali Erdem Baki  Engin Tutkun  Hınç Yılmaz  Tülay Tiftik  Timur Ekiz  Neşe Özgirgin
Affiliation:1.Department of Physical Medicine and Rehabilitation,Ankara Occupational Diseases Hospital,Ankara,Turkey;2.Department of Chest Diseases,Ankara Occupational Diseases Hospital,Ankara,Turkey;3.Department of Toxicology,Ankara Occupational Diseases Hospital,Ankara,Turkey;4.Department of Physical Medicine and Rehabilitation,Ankara Physical Medicine and RehabilitationTraining and Research Hospital,Ankara,Turkey
Abstract:

Objective

The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure.

Materials and methods

The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior–anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25).

Results

Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012).

Conclusion

The results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.
Keywords:Silicosis   Bone mineral density   Osteoporosis   Pneumoconiosis   Vitamin D
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