铜绿假单胞菌亚胺培南耐药株的临床感染及其诱因分析

目的：探讨亚胺培南耐药的铜绿单胞菌临床感染情况及其危险因素。方法：对各种送检的痰、尿、分泌物等标本进行培养并采人汤稀释法对亚胺培南等８种抗生素进行最小抑菌浓度分析。结果：分离的３６．０％铜绿假单胞菌菌株呈现亚胺培南耐药，以ＩＣＵ病房、高干病房的患为主，病情较重，３１．４％的患使用过罗氏芬，２０．０％的患用过泰能。结论：随着抗生素的大量使用，越来越多的铜绿假单胞菌对亚胺培南耐药，多发生于危重、

DETECTION OF IMIPENEM-RESISTANT PSEUDOMONAS AERUGINOSA AND RISK FACTORS

Objective:To explore clinical infectious status of imipenem-resistant Pseudomonas aeruginosa with its risk factors.Methods:Sputum,urine and pus samples from clinical departments were cultured to investigate Pseudomonas aeruginosa. Antibiotic susceptibility patterns was studied by using broth microdilution method.Results:36 0% of strains represented imipenem resistant,mainly isolated from ICU and wards for senior cardres.20 0% of patients got imipenem chemothrapy,31 4% had ceftrixone chemothrapy.Conclusion:More imipenem-resistant Pseudomonas aeruginosa appeared,mainly distributed from critical and immuno-compromised patients.Different exposures to other antimicrobial agents played an important role.