SiRNA和角膜新生血管

角膜病是一类严重的致盲眼病,而角膜新生血管(CNV)是角膜化学伤、外伤、感染等多种疾病的共同病理改变.导致CNV形成的原因仍不明确.血管内皮生长因子(VEGF)可能是CNV形成中最主要的血管形成因子.CNV的治疗方法 包括药物、手术和激光等,但效果均不理想.RNA干扰技术给CNV机制研究和治疗带来新的思路.使用siRNA针对恰当的基因靶点产生沉默效应,是治疗CNV的潜在有效途径.

Small interference RNA and corneal neovascularization

Corneal neovascularization is an extremely common cause induced blindness and visual morbidity.Corneal neovascularization occurs as a consequence of corneal chemical burns,inflammation and infection.Previous studies demonstrated that vascular endothelial growth factor(VEGF) plays a critical role during the pathological angiogenesis of corneal neovascularization.Although the treatments of corneal neovascularization include medicament,surgery and laser,it is thought to be one of the most common and difficult ...