1-deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei |
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Authors: | Shi Qing-Wen Zhao Yong-Ming Si Xiao-Tang Li Zuo-Ping Yamada Teiko Kiyota Hiromasa |
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Affiliation: | Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 050017 Shijiazhuang, Hebei Province, People's Republic of China. qing_wen@hotmail.com |
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Abstract: | A new paclitaxel derivative and two new 2(3-->20)-abeo-taxoids were isolated from a methanol extract of the seeds of Taxus mairei, and their structures were established as 1-deoxypaclitaxel (1), 7beta,10beta-diacetoxy-2alpha,5alpha,13alpha-trihydroxy-2(3-->20)-abeo-taxa-4(20),11-dien-9-one (2), and 2alpha,13alpha-diacetoxy-10beta-hydroxy-2(3-->20)-abeo-taxa-4(20),6,11-triene-5,9-dione (3) on the basis of spectroscopic data analysis. Taxane 1 is the first example of a paclitaxel analogue with a C-1beta hydrogen substituent. Taxane 3 is an 2(3-->20)-abeo-taxane with a rare C-5 ketone and C-6 double bond. |
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