胰高血糖素样肽1对心血管系统影响的研究进展

胰高血糖素样肽1(GLP-1)是一种肠促胰岛素多肽,在调节葡萄糖稳态中发挥重要作用,能够通过多种途径降低血糖,且不易引起低血糖反应,被认为是治疗2型糖尿病的理想药物。已发现GLP-1受体广泛分布于胰腺以外的多种器官和组织,如心血管、胃肠道、肝脏、中枢神经系统等。因此,GLP-1除降低血糖外,尚有诸多胰外作用。在心血管系统中GLP-1可舒张血管、改善内皮功能、促进病理状态下心室功能恢复,并对抗缺血/再灌注及血脂等心血管危险因素亦具有重要作用。

Effects of Glueagon-like Peptide-1 on Cardiovascular System

Glucagon-like peptide-1(GLP-1)is an incretine,which plays an important role in the regulation of glucose homeostasis.It is considered that GLP-1 is the ideal drug for type 2 diabetes mellitus because it can lower blood glucose through various mechanisms and rarely leads to hypoglycemia.GLP-1 receptor(GLP-1R)is widely distributed in the extrapancreatic tissues,such as cardiovascular system,gastrointestinal tract,liver,and central nervous system.In addition,it also has many extra-pancreatic effects.It was demonstrated that GLP-1 could relax vascular vessels,improving endothelial function and promoting the functional recovery of pathological ventricle.It also showed important effects on the amelioration of ischemia-reperfusion and blood lipids.