微生物群体感应调节信号分子N-酰化高丝氨酸内酯研究进展

近10年来,小分子介导的微生物群体感应调节受到广泛关注.介导微生物群体感应调节的信号分子包括AIP、AI-2、DKPs、DPD、N-酰化高丝氨酸内酯(AHL)等,其中AHL成为研究热点,研究表明其具有潜在的抗菌、抗肿瘤、免疫抑制和诱导细胞凋亡等作用.目前对AHL介导微生物群体感应调节机制研究较多,而对于此类化合物的合成...

N-Acyl homoserine lactones as microorganism quorum sensing modulators: research advances

Bacterial quorum sensing demonstrates the ability of bacteria to control gene expression through detecting the minimal threshold stimulatory concentration of certain chemicals called auto inducers, which are secreted by self and/or other bacteria. Quorum sensing has been implicated in the control of bacterial behaviors such as the secretion of virulence factors, biofilm formation, bioluminescence production, conjugation, sporulation and swarming motility. Microorganism quorum sensing mediated by small molecules, including AIP, AI-2, DKPs, DPD and N-acyl homoserine lactones（AHL）, has drawn wide attention in the last ten years. Especially the research on AHL has become a hot topic, a large number of literatures showed that AHL had potential biological activity such as antibacterial, antitumor, immunodepression, cell apoptosis inducer and so on. Much work has been done to explore the action mechanism of AHL to quorum sensing modulation, but it is remaining unclear. What′s more, researches on the synthesis and structure-activity relationship (SAR) of AHL are still on the preliminary stage. Therefore, this paper summarizes the action mechanism, SAR and synthesis of AHL and the analogues, aiming to provide information helpful for new drug discovery and development.