| SDF-1与VEGF在胶质瘤表达中的关系及意义 |
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| 引用本文： | 王宏宇,丁鹏,李玉,龙江,陆斌,宋晓斌. SDF-1与VEGF在胶质瘤表达中的关系及意义[J]. 昆明医学院学报, 2011, 32(5): 36-39 |
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| 作者姓名： | 王宏宇 丁鹏 李玉 龙江 陆斌 宋晓斌 |
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| 作者单位： | 昆明医学院第一附属医院神经外科,云南,昆明,650032 |
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| 基金项目： | 云南省科技计划资助项目 |
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| 摘 要： | 目的检测基质细胞衍化因子SDF-1和血管内皮生长因子VEGF在神经胶质瘤中的表达,探讨二者在胶质瘤中的表达关系.方法手术取胶质瘤标本32例,Ⅰ～Ⅳ级各8例,以免疫组化法行胶质瘤标本SDF-1和VEGF染色,分别检测SDF-1和VEGF在不同分级胶质瘤中的表达.结果 SDF-1和VEGF在胶质瘤标本中的表达与分级密切相关,SDF-1和VEGF表达的阳性率明显随级别增高而表达增强（P〈0.05）,且肿瘤中SDF-1和VEGF的表达呈正相关（P〈0.05）.结论 SDF-1和VEGF在胶质瘤发生发展中可能具有协同作用,在肿瘤进展中可能有一定促进作用,联合检测SDF-1和VEGF可能有助于判断胶质瘤的恶性程度.
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| 关 键 词： | 胶质瘤 基质细胞衍生因子 血管内皮生长因子 免疫组化 |
The Expression Significance and Relationship Study of SDF-1 and VEGF in Glioma |
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| WANG Hong-yu,DING Peng,LI Yu,LONG Jiang,LU Bin,SONG Xiao-bin. The Expression Significance and Relationship Study of SDF-1 and VEGF in Glioma[J]. Journal of Kunming Medical College, 2011, 32(5): 36-39 |
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| Authors: | WANG Hong-yu DING Peng LI Yu LONG Jiang LU Bin SONG Xiao-bin |
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| Affiliation: | WANG Hong-yu,DING Peng,LI Yu,LONG Jiang,LU Bin,SONG Xiao-bin(Dept.of Neurosurgery,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China) |
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| Abstract: | Objective To detect the expression of SDF-l and VEGF protein.and investigate their relationship and significance in glioma.Method We detected the expresion of SDF-l and VEGF in glioma by using IHC in 32 cases,8 cases in each level(I-IV).Results The expression of SDF-1 and VEGF was correlated with tumor grade.Positive correlation between SDF-l and VEGF was found in glioma.Conclusions The expression of SDF-1 and VEGF may has synergetic effect and promote the occurrence and development of glioma.Combined deter... |
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| Keywords: | Glioma SDF-1 VEGF IHC |
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