Metabonomics Techniques and Applications to Pharmaceutical Research & Development |
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Authors: | John C Lindon Elaine Holmes Jeremy K Nicholson |
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Institution: | (1) Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK |
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Abstract: | In this review, the background to the approach known as metabonomics is provided, giving a brief historical perspective and
summarizing the analytical and statistical techniques used. Some of the major applications of metabonomics relevant to pharmaceutical
Research & Development are then reviewed including the study of various influences on metabolism, such as diet, lifestyle,
and other environmental factors. The applications of metabonomics in drug safety studies are explained with special reference
to the aims and achievements of the Consortium for Metabonomic Toxicology. Next, the role that metabonomics might have in
disease diagnosis and therapy monitoring is provided with some examples, and the concept of pharmacometabonomics as a way
of predicting an individual's response to treatment is highlighted. Some discussion is given on the strengths and weaknesses,
opportunities of, and threats to metabonomics. |
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Keywords: | biomarkers diagnostics drug safety metabonomics spectroscopy |
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