不同程度低氧对阻塞性睡眠呼吸暂停低通气综合征患者认知功能及血清5-羟色胺水平的影响

摘要:目的　探讨不同程度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者认知功能障碍发生与血清中5-羟色胺（5-HT）的关系。方法　根据睡眠呼吸暂停低通气指数与血氧饱和度把夜间打鼾、白天嗜睡受试者分为三组（正常对照组，轻中度OSAHS组，重度OSAHS组），计算所有受试者的体重指数，通过蒙特利尔认知评估量表（MoCA）检测患者认知功能，采用酶联免疫吸附法（ELISA）法测定血清5-HT的水平。结果　与对照组比较，OSAHS两组均有认知功能损害，且重度OSAHS组认知功能损害较重；OSAHS两组血清中5-HT水平明显升高，以重度OSAHS组5-HT水平的升高更为显著。结论　不同程度OSAHS患者均存在认知功能障碍，低氧程度越重，认知功能损害越严重，且与5-HT水平呈负相关。

The influence of the degree of hypoxia on the cognitive function and level of serum 5-HT in the patients with OSAHS

Abstract: Objective To study the relationship of the different degree of Obstructive Sleep Apnea Hypoxia Syndrome (OSAHS) patients with cognitive dysfunction and serum serotonin (5-HT). Methods All the people of the night snoring and daytime sleepiness were divided into three groups (normal control group, mild-to-moderate OSAHS group and severe OSAHS group), according to the sleep apnea hypoventilation index and blood oxygen saturation. Body mass index of all the subjects were calculated, and cognitive dysfunction of patients were detected by the Montreal cognitive assessment scale (MoCA), the levels of serum 5-HT were determined by enzyme-linked immunosorbent (ELISA) method. Results Compared with control group, two groups of OSAHS had cognitive impairment, and with severe of hypoxia, the damage of cognitive impairment was more significant. The 5-HT levels in serum increased significantly in two groups of OSAHS, and with severe OSAHS group, the 5-HT levels increased more significantly. Conclusion Different level of cognitive dysfunction occurred in OSAHS patients. The more hypoxia, the more serious cognitive impairment is. It is negative correlation between the level of 5-HT and the cognitive function.