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Reducing acute respiratory distress syndrome occurrence using mechanical ventilation |
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| Authors: | Gary F Nieman Louis A Gatto Nader M Habashi |
| Institution: | Gary F Nieman, Department of Surgery, Upstate Medical University, Syracuse, NY 13210, United StatesLouis A Gatto, Biology Department, SUNY Cortland, Cortland, NY 13210, United StatesNader M Habashi, Department of Trauma Critical Care Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD 21201, United States |
| Abstract: | The standard treatment for acute respiratory distress syndrome (ARDS) is supportive in the form of low tidal volume ventilation applied after significant lung injury has already developed. Nevertheless, ARDS mortality remains unacceptably high (> 40%). Indeed, once ARDS is established it becomes refractory to treatment, and therefore avoidance is key. However, preventive techniques and therapeutics to reduce the incidence of ARDS in patients at high-risk have not been validated clinically. This review discusses the current data suggesting that preemptive application of the properly adjusted mechanical breath can block progressive acute lung injury and significantly reduce the occurrence of ARDS. |
| Keywords: | Acute respiratory distress syndrome Ventilator induced lung injury Early acute lung injury Mechanical ventilation Acute respiratory distress syndrome incidence Airway pressure release ventilation Acute respiratory distress syndrome pathophysiology |
| 点击此处可从《World Journal of Respirology》浏览原始摘要信息 | |