生物活性玻璃抑制酸蚀后不同时间牙釉质的刷牙磨损

背景：生物活性玻璃具有良好的生物相容性，并具有优异的促进牙齿再矿化和抗酸蚀效果。 目的：比较生物活性玻璃牙膏和含氟牙膏对牙釉质酸蚀后不同时间点刷牙磨损的影响。 方法：制备56个牛牙釉质片，树脂包埋并暴露大小约6 mm×6 mm的釉质平面，表面制备沟槽并充填银汞合金，磨平抛光后随机均分为7组，模拟酸性饮食后刷牙的过程，其中6组分别用普通牙膏、含氟牙膏、生物活性玻璃牙膏在雪碧酸蚀后即刻和酸蚀后30 min两个时间点以牙刷磨刷，另1组不酸蚀，只用普通牙膏磨刷，为无酸蚀对照组，过程循环60次。以银汞合金为参照，用激光共聚焦显微镜观察各组样本磨刷后的表面磨损量。 结果与结论：酸蚀后刷牙各组磨损量明显高于无酸蚀对照组(P < 0.05)。在酸蚀后同一时间刷牙条件下，生物活性玻璃牙膏组磨损量均低于含氟牙膏组(P < 0.05)；使用同种牙膏条件下，牙齿酸蚀后唾液浸泡30 min后刷牙组的磨损量均低于酸蚀后即刻组(P < 0.05)。说明应用生物活性玻璃牙膏在酸性饮食30 min后刷牙，可有效减少刷牙对酸蚀牙釉质的磨损。  中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Brushing abrasion of eroded enamel using bioactive glass toothpaste in different time after acid etching

BACKGROUND:Bioactive glass has good biocompatibility, which can promote the remineralization effects of demineralized enamel and enhance the resistance of enamel to erosion. OBJECTIVE:To evaluate the effect of bioactive glass toothpaste versus fluoride toothpaste on brushing abrasion of enamel after acid etching. METHODS:Fifty-six enamel specimens were prepared from bovine incisors, and were embedded in acrylic resin with exposed buccal surface. The exposed area was 6 mm×6 mm and two amalgam fillings were placed into the enamel and polished. All specimens were divided into seven groups with eight specimens each. In six groups, specimens were brushed with ordinary toothpaste, fluoride toothpaste, bioactive glass toothpaste immediately and 30 minutes after being eroded by the Sprite. The last one group was brushed with ordinary toothpaste without acid etching as control. The treatment course was cycled 60 times. The surface abrasion loss of the specimens between two amalgam fillings compared with respective amalgam reference surfaces was finally observed and calculated under laser scanning confocal microscope. RESULTS AND CONCLUSION:The abrasion loss amount of teeth with no acid etching was significantly lower than that with acid etching (P < 0.05). The abrasion loss amount of teeth brushed with bioactive glass toothpaste  was less than that with fluoride toothpaste at the same brushing time (P < 0.05). For the same toothpaste, the abrasion loss amount of teeth brushed 30 minutes after eroded was less than that bushed instantly after eroded (P < 0.05). Use of bioactive glass toothpaste can effectively reduce enamel loss caused by acid etching and brushing. The loss amount can also be reduced by brushing teeth 30 minutes after acid etching.