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| 中国儿童急性淋巴细胞白血病患者Cyclin D1基因多态性的探讨 | |
| 引用本文： | 王思力,侯续伟,宋嘉,许子亮,周毓玲,李青山,姚蓉,韩明哲,韩忠朝. 中国儿童急性淋巴细胞白血病患者Cyclin D1基因多态性的探讨[J]. 中国肿瘤临床, 2006, 33(3): 126-129 |
| 作者姓名： | 王思力 侯续伟 宋嘉 许子亮 周毓玲 李青山 姚蓉 韩明哲 韩忠朝 |
| 作者单位： | 1. 吉林大学生命科学院 2. 中国医学科学院血液学研究所,血液病医院实验血液学,国家重点实验室,天津市,300020 3. 天津医科大学总医院 |
| 基金项目： | 中国科学院资助项目;国家高技术研究发展计划(863计划) |
| 摘 要： | 目的:探讨细胞周期蛋白CyclinD1外显子4(870A/G)多态性与儿童急性淋巴细胞白血病(ALL)的相关性。方法:采用聚合酶链反应(PCR)和PCR-RFLP方法,分析183例儿童ALL患者和190例健康对照者的CyclinD1基因型。结果:与健康对照组相比,携带AA基因型者患ALL的相对风险度增加3.2898(P=0.0207);携带AA型的T-ALL患者显著高于B-ALL患者(P=0.047);携带AA型的ALL高危患者显著高于标危患者(P=0.011)。结论:Cy-clinD1基因多态性与中国儿童ALL的发生、发展及预后密切相关。 |
| 关 键 词： | 白血病 多态性 儿童 中国 |
| 文章编号： | 1000-8179（2006）03-0126-04 |
| 收稿时间： | 2005-05-23 |
| 修稿时间： | 2005-05-232005-10-19 |
Approach on the Polymorphism of Cyclin D1 for Chinese Children Patients with Acute Lymphoblastic Leukemia |
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| Wang Sili, Hou Xuwei, Song Jia, et al. Approach on the Polymorphism of Cyclin D1 for Chinese Children Patients with Acute Lymphoblastic Leukemia[J]. Chinese Journal of Clinical Oncology, 2006, 33(3): 126-129 | |
| Authors: | Wang Sili Hou Xuwei Song Jia et al |
| Affiliation: | Department of Internal Medicine, Blood Disease Hospital of Chinese Academy of Medical Sciences and Chinese Union Medical University, Tianjin |
| Abstract: | Objective: To approach the dependability between polymorphism of the exon 4(870 A/G) of cyclin D1 and Acute Lymphoblastic Leukemia (ALL) in children. Methods: A case-control study consisting of 183 children ALL patients and 190 controls in a Chinese population was performed to examine the genotypic frequency of the cyclin D1 polymorphism. Results: The genetic frequency of cyclin D1 significantly correlated with overall patients and controls. AA genotype of cyclin D1 showed a tendency to increase ALL risk by 3.289 8-fold compared to AG GG (P=0.020 7). Stratification of patients according to cell type, risk level and the chemotherapeutic response showed that the AA genotype was clearly observed in T-ALL, and the ALL with high risk (P=0.047 and P= 0.011 respectively). No gene dosage effect was observed in this study. Conclusion: The cyclin D1 genetic polymorphism might be closely related to the occurrence of children ALL in the Chinese population. |
| Keywords: | Cyclin D1 |
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