Spectrum effects of a new polypeptide (third hormone?) isolated from the chicken pancreas

A broad evaluation was made of the biological effects of a new polypeptide (APP), 36 amino acid residues, MW 4200, isolated from the chicken pancreas. APP is an effective hepatic glycogenolytic and plasma hypoglycerolemic agent in the absence of plasma glucose perturbation. APP (at much lower doses) is also a powerful gastric secretogogue, inducing within seconds marked increases in proventricular volume, H⁺, pepsin, and total protein release. Such proventricular response is not mediated through systemic cardiovascular alterations or the vagus nerves, and are quite opposite to those observed with beef or chicken glucagon. It is concluded that the chicken pancreas releases APP to exert a “gastrinlike” secretogogic action on the proventriculus and, at higher concentrations, a metabolic action as well.