滇白珠木脂素苷的研究

目的： 研究民间药滇白珠(Gaultheria yunnanensis (Franch.) Rehd.)的化学成分。方法： 用95%乙醇提取，硅胶柱色谱和聚酰胺柱色谱分离纯化，通过各种光谱分析鉴定其结构。结果： 从正丁醇萃取物中分离鉴定了4个木脂素苷类化合物。其结构分别鉴定为(-)-isolariciresinol-2a-O-β-D-xylopyranoside (D₁)，(+)-lyoniresinol-2a-O-β-L-arabinopyranoside (D₂)，(-)-5′-methoxyisolariciresinol-2a-O-β-D-xylopyranoside (D₃)和(+)-lyoniresinol-2a-O-β-D-glucopyranoside (D₄)。结论： 化合物D2为一新化合物，命名为滇白珠苷A(Gaultheroside A)，D₁，D₃，D₄为首次从杜鹃花科植物中分得。

STUDIES ON THE LIGNAN GLYCOSIDES FROM GAULTHERIA YUNNANENSIS

AIM: To study the chemical constituents of the Chinese herbal drug Dianbaizhu, the root of Gaultheria yunnanensis, in order to determine its active constituents. METHODS: Using 95% ethanol extraction, silica gel and polyamide column chromatography and various spectral analysis to isolate pure compounds and determine their structures. RESULTS: Four lignan glycosides have been isolated from the n-butanol fraction of the roots of Gaultheria yunnanensis. On the basis of physicochemical and spectral data, they were elucidated as (-)-isolariciresinol-2a-O-β-D-xylopyranoside (D_{1), (+)-lyoniresinol-2a-O-α-L-arabinopyranoside (D2), (-)-5′-methoxyisolariciresinol-2a-O-β-D-xylopyranoside (D3) and (+)-lyoniresinol-2a-O-β-D-glucopyranoside (D4). CONCLUSION: Compound D2 is a new compound named gaultheroside A, while D1, D3 and D4 were isolated form the family Ericaceae for the first time.}