注射用头孢硫脒与注射用阿昔洛韦的配伍稳定性考察

目的:考察注射用头孢硫脒与注射用阿昔洛韦分别在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在室温(25±1)℃、不避光条件下,观察并测定6h内配伍液的外观和pH值变化,采用高效液相色谱法测定2种药的含量并考察有无新物质生成。结果:2种药在0.9%氯化钠注射液、5%葡萄糖注射液中配伍后6h内外观呈现淡黄色并随时间延长颜色有逐步变深的趋势,pH值逐渐下降,头孢硫脒含量显著下降。结论:注射用头孢硫脒不能与注射用阿昔洛韦在0.9%氯化钠注射液、5%葡萄糖注射液中配伍使用。

Compatible Stability of Cefathiamidine for Injection in Combination with Acyclovir for Injection

OBJECTIVE:To study the compatible stability of Cefathiamidine for injection with Acyclovir for injection in 0.9% Sodium chloride injection or in 5% Glucose injection.METHODS:Under light,at room temperature(25±1)℃,the changes of the mixture in appearance and pH value within 6 h were observed respectively,and the contents of cefathiamidine and acyclovir were determined by HPLC to investigate the generation of new substance.RESULTS:Within 6 hours,the color of the mixture in 0.9% Sodium chloride injection or in 5% Glucose injection became deep gradually.The pH value and the content of cefathiamidine came down significantly.CONCLUSION:Cefathiamidine for injection can not be mixed with Acyclovir for injection in 0.9% Sodium chloride injection or 5% Glucose injection to use.