DIISOPROPANOLNITROSAMINE (DIPN) INDUCED RAT THYROID LESIONS |
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| Authors: | Akira Kawaoi Shinichi Moriyama |
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| Affiliation: | Department of Pathology, Yamanashi Medical College;*Division of Surgical Pathology, Nagano Red Cross Hospital |
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| Abstract: | DIPN induced localized lesions of the rat thyroid gland are described histologically and classified into three major types: type 1, foci of cellular alteration; type 2, proliferative nodules; and type 3, overt carcinomas. Follicular, papillary and mixed papillofollicular subtypes are recognized in the type 2 lesions, and follicular, papillary, anaplastic and mixed subtypes in the type 3 lesions. The nature of the individual lesions is discussed. |
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