肝细胞肝癌中微血管密度及MMP-2 和MMP-9 的表达与术后转移及预后的关系* |
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引用本文: | 赵占考,孙保存,孙涛,赵秀兰,古强,车娜,董学易,孙丹.肝细胞肝癌中微血管密度及MMP-2 和MMP-9 的表达与术后转移及预后的关系*[J].中国肿瘤临床,2010,37(7):385-387. |
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作者姓名: | 赵占考 孙保存 孙涛 赵秀兰 古强 车娜 董学易 孙丹 |
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作者单位: | 作者单位:武警医学院附属医院病理科(天津市300162);①天津医科大学附属肿瘤医院病理科 |
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基金项目: | 天津市应用基础及前沿技术研究计划重点项目,天津市应用基础及前沿技术研究计划面上项目,天津市科技支撑项目(中瑞国际合作) |
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摘 要: | 目的:探讨微血管密度(MVD)、基质金属蛋白酶-2(MMP-2)和MMP-9 在肝细胞肝癌转移中的作用及其各自和预后的相关性。方法:以石蜡包埋组织切片,免疫组化SP法染色分别检测97例肝细胞肝癌MVD和MMP-2、MMP-9 表达的情况,其中复发与转移组49例,非复发与转移组48例。结果:转移组MVD高于无转移组(P=0.015),转移组MMP-2 和MMP-9 表达高于无发转移组(P=0.009,P=0.043),差异具有统计学意义。结论:MVD增高、MMP-2 和MMP-9 过度表达可能与肝细胞肝癌转移、不良生存预后存在相关性。
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关 键 词: | MVD MMP-2 MMP-9 转移 |
收稿时间: | 2009-12-18 |
The Microvessel Density and Expression of MMP-2 and MMP-9 in Hepatocellular Carcinoma and Their Correlation with Metastasis and Prognosis |
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Institution: | 1Department of Pathology, Affiliated Hospital of Medical College of Chinese People’s Army Police Force, Tianjin300162, China |
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Abstract: | Objective:To investigate the effect of microvessel density and expression of MMP-2 and MMP-9 on the me-tastasis of hepatocellular carcinoma and their correlation with patients'prognosis.Methods:Immunohistochemistry(SP)was employed to detect MVD and expression of MMP-2 and MMP-9 in 97 samples of hepatocellular carcinoma.There were 49 cases with metastasis and 48 cases with no metastasis.Results:The abnormal MVD and expression of MMP-2 and MMP-9 in cases with metastasis were higher than those in cases with no metastasis(P=0.015;P=0.009).Conclusion:Abnomal MVD and expression of MMP-2 and MMP-9 may play an important role in the metastasis of hepatocellular carci-noma and indicate poor prognosis. |
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Keywords: | MVD MMP-2 MMP-9 MVD MMP-2 MMP-9 Metastasis |
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