| Expression of Costimulatory Molecules B7／CD28 in Systemic Lupus Erythematosus |
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| 引用本文： | 胡绍先,陶德定,何培根.Expression of Costimulatory Molecules B7／CD28 in Systemic Lupus Erythematosus[J].华中科技大学学报(医学英德文版),2004,24(3):245-246,265. |
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| 作者姓名： | 胡绍先 陶德定 何培根 |
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| 作者单位： | Department of Rheumatology，Institute of Molecular Medical Center，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Rheumatology |
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| 摘 要： | Systemiclupuserythematosus (SLE)isacom monchronicinflammatorydiseasewhichderivesfromimmunoloregulationdisorderofbody ,anditsetiologyandpathogenesisareunknown .Inrecentyears ,thestudiesreportedthatthe pathogenesisofSLEwascorrelatedwiththeabnormalpathwayofc…
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| 关 键 词： | 辅助刺激因子 B7／CD28因子 系统性红斑狼疮 PBMC 发病机理 |
Expression of Costimulatory Molecules B7/CD28 in Systemic Lupus Erythematosus |
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| HU Shaoxian,TAO Deding,HE Peigen.Expression of Costimulatory Molecules B7/CD28 in Systemic Lupus Erythematosus[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(3):245-246,265. |
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| Authors: | HU Shaoxian TAO Deding HE Peigen |
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| Institution: | HU Shaoxian1,TAO Deding2,HE Peigen1 1 Department of Rheumatology,2 Institute of Molecular Medical Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Summary: The expression of the costimulatory molecules B7/CD28 in peripheral blood mononuclear cells (PBMC) of the patients with systemic lupus erythematosus (SLE) and its relation to the pathogenesis of SLE were studied. The expression of the costimulatory molecules in PBMC in 30 patients with active SLE and 20 cases of healthy controls was detected by using the techniques of immunofluorescence and flow cytometer. The result showed that the expression percentage of CD28 , CD4 CD28 in T cells of PBMC from the patients with SLE decreased significantly as compared with that in healthy control group, while the expression percentage of CD80 , CD19 CD80 in B cells was significantly increased than that in healthy control group (P<0.01). It suggested that the abnormal expression of costimulatory molecules B7/CD28 played a role in the pathogenesis of SLE. |
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| Keywords: | systemic lupus erythematosus costimulatory molecules flow cytometer |
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