Tissue factor-dependent factor VIIa signaling |
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| Authors: | Petersen L C Freskgård P Ezban M |
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| Affiliation: | 1. Worldwide Network for Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital, Basel, Switzerland;2. The Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, USA;3. The Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia;4. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan;5. World Marrow Donor Association, Europdonor Foundation, Leiden, Netherlands;6. Institute for Operations Research and Computational Finances, University of St Gallen, Switzerland;7. The Latin American Blood and Marrow Transplantation Group (LABMT), Instituto Nacional de Cancer, Rio de Janeiro, Brazil;8. National Marrow Donor Program, Minneapolis, USA;9. Eurocord Foundation, Paris, France;10. Medical Clinic, University of Vienna, Vienna, Austria;11. The Asian Pacific Blood and Marrow Transplantation Group (APBMT) Data Centre, Aichi Medical University, School of Medicine, Japan;12. The Canadian Blood and Marrow Transplantation Group (CBMTG), Princess Margaret Hospital, Toronto, Canada;13. Anthony Nolan Research Institute, Royal Free and University College London, UK;14. The European Society for Blood and Marrow Transplantation (EBMT), Hôpital St. Antoine, Paris, France;15. WHO, Geneva, Switzerland;p. The African Blood and Marrow Transplantation Group (AFBMT), Johannesburg, South Africa;q. Bone Marrow Donors Worldwide, Leiden, Netherlands;r. The Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Royal Melbourne Hospital, Parkville, Victoria, Australia;s. Stanford University School of Medicine, Standford, USA;t. Fred Hutchinson Cancer Research Center, Seattle, USA;u. Aichi Medical University, School of Medicine, Japan;v. Hematology-Oncology Department, University Hospital, Leipzig, Germany;1. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China;2. State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution, Chinese Research Academy of Environmental Sciences, Beijing 100012, China;3. College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China;4. College of Water Sciences, Beijing Normal University, Beijing 100875, China;5. School of Life Sciences, South China Normal University, Guangzhou 510631, China;1. Pharmaceutical Chemistry Department, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia;2. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;3. Department of Pharmacy, Abdul Wali Khan University Mardan, Pakistan;1. Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan;2. Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan;3. Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany;1. Department of Pathology, The University of Chicago, Chicago, Illinois;2. Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, Illinois;3. Department of Pediatrics, The University of Chicago, Chicago, Illinois;4. Department of Medicine, The University of Chicago, Chicago, Illinois;5. Section of Pulmonary and Critical Care, The University of Chicago, Chicago, Illinois |
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| Abstract: | Tissue factor (TF) is known primary as a cofactor for factor VIIa-mediated triggering of blood coagulation, which proceeds in a cascade of extracellular reactions. Recent investigations have, however, revealed that intracellular activities can also be induced by the proteolytic activity of factor VIIa bound to cell surface TF. Factor VIIa signal transduction has thus been reported to induce mobilization of intracellular Ca(2+) stores and p44/p42 MAPK phosphorylation and to result in expression of specific genes, which presumably affects a number of cellular functions. The factor VIIa-induced signal transduction is independent of the presence of the TF cytoplasmic domain and it is distinctly different from signaling involving presently known protease-activated receptors (PARs) including receptors for thrombin and factor Xa. This short review summarizes recent advances in our understanding of TF-dependent factor VIIa signaling. |
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